TNBS-induced visceral hypersensitivity in mice 2

Altered colorectal afferent function associated with 1 TNBS-induced visceral hypersensitivity in mice 2 Bin Feng, Jun-Ho La, Takahiro Tanaka, Erica S. Schwartz, Timothy P. 3 McMurray and G.F. Gebhart 4 Center for Pain Research, Department of Anesthesiology, School of Medicine, 5 University of Pittsburgh, Pittsburgh, PA 15213, USA 6 Current address: Takeda Pharmaceutical Company Limited, Osaka, Japan 7 8 Running head: colorectal afferents and TNBS-induced hypersensitivity 9 Abbreviations: TNBS, 2,4,6-Trinitrobenzene sulfonic acid; PI-IBS, 10 post-infectious Irritable bowel syndrome; CRD, colorectal distension; PN, 11 pelvic nerve; MIAs, mechanically insensitive afferents 12 13 Correspondence: 14 B. Feng, Ph.D. 15 Center for Pain Research, University of Pittsburgh 16 W1402 BST, 200 Lothrop St., Pittsburgh, PA 15213, USA 17 e-mail: fengb@upmc.edu 18 phone: 412-648-8123, fax: 412-383-5466 19 20 Articles in PresS. Am J Physiol Gastrointest Liver Physiol (August 2, 2012). doi:10.1152/ajpgi.00257.2012