Influence of endometrial mechanical stimulation on clinical pregnancy rate of intrauterine insemination

The first line of fertility treatment frequently applied in the world is intrauterine insemination (IUI) with ovarian stimulation. The effectiveness of this procedure is, however, still low. There is evidence of significant difference on the clinical pregnancy rate when endometrial scratching performed prior to embryo transfer in women undergoing in vitro fertilization-embryo transfer (IVF-ET), who stand with repeated transfer failure. Is it also beneficial to IUI? Here, we present an overview about the up to date mechanism and the role of endometrial injury in the cycle preceding ovarian stimulation for IUI cycle on the clinical pregnancy rate. Key words: Endometrial scrach; Endometrial local injury; Intrauterine insemination (IUI); Endometrial receptivity; Clinical pregnancy rate