Randomized Phase IIIb study of rapid vitamin K antagonist reversal in patients requiring an urgent surgical procedure: four-factor prothrombin complex concentrate is superior to plasma

Majed A. Refaai, MD,1 Joshua N. Goldstein, MD, PhD,2 Truman J. Milling Jr., MD,3 Brandon Lewis, DO,4 Robert Goldberg-Alberts, MA,5 Bruce A. Hug, MD, PhD,5 Ravi Sarode, MD6 University of Rochester Medical Center, Rochester, NY, USA; Massachusetts General Hospital, Boston, MA, USA; Seton/UT Southwestern Clinical Research Institute of Austin, Dell Children’s Medical Center, University Medical Center at Brackenridge, Austin, TX, USA; St Joseph Regional Health Center, Bryan, TX, Texas AM CSL Behring LLC, King of Prussia, PA, USA; UT Southwestern Medical Center, Dallas, TX, USA 3588