identification of new molecular markers of thyroid cancer progression

Anaplastic thyorid cancer is the most lethal subtype of thyroid carcinoma and it is characterized by local invasion, distant metastasis, chemo and radio-resistance. We have identify new molecular determinants involved in thyroid cancer progression: TUSC2 and the adhesion molecule JAM-A. We stably transfected TUSC2 and JAM-A in papillary (TPC-1) and anaplastic(8505C) thyroid cancer cells and studied their effects on proliferation, migration and invasion.