Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034.

Stephane L. Bogen,Ashok Arasappan,Weidong Pan,Sumei Ruan,Angela I. Padilla,Anil K. Saksena,Viyyoor M. Girijavallabhan,F. Njoroge

Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034.

2008

Stephane L. Bogen
Ashok Arasappan
Weidong Pan
Sumei Ruan
Angela I. Padilla
Anil K. Saksena
Viyyoor M. Girijavallabhan
F. Njoroge

Abstract Substitutions on the P 1 cyclobutyl side chain of SCH 503034 were studied by introduction of hydroxyl and fluoro substituents. Additionally, effects of fluoro substitution on other P1 moieties were evaluated.

Keywords:

Hepatitis C virus
Enzyme
Chemical synthesis
Side chain
Organic chemistry
Dipeptide
NS3
Biochemistry
Stereochemistry
Enzyme inhibitor
Peptide
Chemistry
Serine Proteinase Inhibitors
Stereoisomerism
Structure–activity relationship

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