The Genetics of Mitral Valve Prolapse

Mitral valve prolapse (MVP) is one of the most common forms of valvular heart disease. The clinical presentation can be very diverse, ranging from an incidental finding within asymptomatic patients to dramatic cases with severe mitral regurgitation, heart failure, bacterial endocarditis, or even sudden cardiac death. Mitral valve prolapse appears to be one of the most common Mendelian cardiovascular abnormalities in humans. This chapter briefly discusses the epidemiologic aspects of mitral valve prolapse, its pathophysiology, and the current status of genetic knowledge of this intriguing valvular disorder.