Effect of Chitosan and Curcumin Complex on the Full-thickness Skin Wound Healing in Rabbits

The purpose of this study was to examine the effect of Chitosan-curcumin (CTSN-cur) complex on the full-thickness skin wound healing in rabbits. Five healthy adult New Zealand rabbit were used and 4 full thickness skin defects were made in the dorsal skin of the trunk. The experimental groups were divided according to the applied materials: control group; saline treatment, hyaluronic acid (HA) group; 0.5% HA treatment, CTSN Group; 0.5% CTSN treatment, CTSN-cur group; 0.5% CTSN-cur complex treatment. Biopsy was performed immediately after euthanasia on day 14. This study showed that more significant accelerating effects on the full-thickness wound healings were detected in CTSN-cur applied wounds as compared with other treated wounds. CTSN-cur applied wounds showed more rapid wound contraction, more rapid reconstruction of granulation tissues such as increase of re-epithelization rates, less neovascularization, less inflammatory cell infiltrations, more rapid collagen fiber regenerations, and decrease of granulation tissues area as compared with other treated wounds. Therefore, it was concluded that CTSN-cur may be useful as a wound healing regulator for the treatment of skin wound defects.