Muerte súbita en pacientes esquizofrénicos en tratamiento con antipsicóticos

Sudden Death in Schizophrenic Patients in Treatment with Antipsychotic. Schizophrenia intensity and its evolution depend on the alteration of certain neuronal centres and on the interaction among the severity of such alterations and the fluctuations of diverse neurotransmitters and neuromodulators, among them, dopamine. Maybe due this complexity and the heterogeneity both in its origin and in its evolution, it due patients' cases treated with antipsychotic, physiologically stabilized from that there is not hoped an unfavorable evolution that they suffer an unexpected death. In this sense, one case is considered with fatal conclusion in a patient who was enduring arterial hypertension, diabetes mellitus and hebephrenic schizophrenia in treatment with thioridazine. This substance is analyzed by gas chromatography in tandem with mass spectrometry (GC/MS) found a sanguineous level of 2,39 mg/L. Studying the above mentioned case and taking account others similar; it can be obtained considerations that could be useful in the evaluation of these therapeutic agents.