Prevention of Contrast Medium Induced Nephropathy by Liposome Encapsulation

Abstract—The study is investigating prospectively the potentials of applying liposome as computed tomography (CT) contrast agent delivery vesicle for prevention of contrast medium induced nephropathy (CIN) incidence both in vitro and in vivo. From dynamic CT of nude mice, we found that partial encapsulation of CM in liposome increased the indication of biliary excretion up to 12 folds post CM administration, and reduced the concentration and duration of CM accumulation in kidney. From Madin–Darby canine kidney epithelial cell line (MDCK) viability studies, it showed that fully encapsulation of CM in liposome significantly improved the cell viability when exposed to clinical concentration of CM for 24 hours.