Acute intoxication by synthetic cannabinoids – Four case reports

receptor-mediated effectsare changes in mood, pain perception, state of arousal, bodytemperature, cardiovascular regulation, and food intake.Recently, synthetic cannabinoids appeared on the drugmarket, mostly as undeclared additives in ‘herbal mixtures’ namedfor example ‘Spice’, ‘Lava Red’ or ‘Jamaican Gold’. The use ofsynthetic cannabinoids is driven by several factors. After the intro-duction of new compounds, their use is initially not restricted byprohibition. Moreover, their consumption cannot be verified bystandard drug tests, which is particularly interesting for peoplefacing regular drugtesting.Easy accessvia the Internetand afford-ability also contribute to the popularity of these drugs.Since their first detection in herbal mixtures,