Spatial memory using active allothetic place avoidance in adult rats after isoflurane anesthesia: A potential model for postoperative cognitive dysfunction

BackgroundWe described a paradigm of active allothetic place avoidance (AAPA) as a measure of spatial memory in adult rats. We hypothesized that, pending successful AAPA training, treatment with isoflurane would trigger spatial memory deficits.MethodsFifteen of 20 adult rats were successfully traine