Clinical study for compostion of urinary calculi and metabolic abnormality

Objective To explore the relationship between calculus composition and metabolic abnormality in patients with urinary calculi. Methods 200 cases of urinary calculi were collected with samples of calculi, serum and urine samples, the composition of calculus and blood /urine metabolism were measured. Results 86 (43%) of the patients were analyzed with calculus of calcium oxalate. Metabolic abnormalities were found in 90.5% of the patients, most frequently with hyperoxalic acid (64.5%), followed by hypercalciuria, hypercalcemia, hypocitric acid and hyperuricemia. High oxalic acid urine induced calcium oxalate stone, the mixed composition stone of calcium oxalate/calcium phosphate and calcium oxalate/uric acid ;low citric acid urine induced calcium oxalate and calcium phosphate stones; Hypernatremia and hyperuricemia are all induce calcium oxalate calculi; Homocysteine only induced cysteine calculi. Conclusions Metabolic abnormalities are common in patients with urinary calculus, most of which are high oxalate, hypercalciuria, hypercalcemia, low citrate, hyperuricemia. Metabolic abnormalities can induce calculi, calculus composition and metabolic analysis can help to choose appropriate medical treatment and adjust dietary habits which can prevent the recurrence of stones. Key words: Urinary; Calculus composition; Metabolic abnormality