α-(1H-Imidazol-1-yl)alkyl (IMIDA) carboxylic acid esters as prodrugs of carboxylic acid containing drugs

Susruta Majumdar,Maren Mueller-Spaeth,Sashikala Sivendran,Juha Juntunen,Joshua Thomas,Kenneth B. Sloan

α-(1H-Imidazol-1-yl)alkyl (IMIDA) carboxylic acid esters as prodrugs of carboxylic acid containing drugs

2007

Susruta Majumdar
Maren Mueller-Spaeth
Sashikala Sivendran
Juha Juntunen
Joshua Thomas
Kenneth B. Sloan

Abstract Synthesis of α-(1 H -imidazol-1-yl)alkyl (IMIDA) carboxylic acid esters have been reported in 2–3 simple steps. α-(1 H -Imidazol-1-yl)alkyl (IMIDA) carboxylic acid esters were found to be chemically labile and thus serve as novel prodrugs of carboxylic acids.

Keywords:

Alkyl
Carboxylic acid
Organic chemistry
Prodrug
Chemistry
Biochemistry

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