Evaluation of Celecoxib Effect in Reducing Oral Ibuprofen after Third Molar Surgery

Introduction: Recent anti-inflammatory group of medications include the introduction of cyclooxygenase-II inhibitors such as coxibs. These agents offer potentially significant advantages because of their realive lack of gastrointestinal irritation. The aim of this study was to evaluate the effect third molar surgery. Methods and materials: This study was a double, randomized, cross over, clinical trial. Fourteen patients in age range of 17-30 years that acted as their own controls underwent bilateral third molar surgery with an interval of 2 weeks between each operation, when the tooth was removed in attention to right or left side of surgery, patients were randomly entered in study every twelve houres, ibuprofen 400mg was taken if pain persisted. Patients in control group took ibuprofen 400mg upon pain. The number of additional analgesic and the time of intake were recorded by patients. Result: There was no significant difference between mean pain intensity in study and control group. The number of ibuprofen used in the study group was less significant. But the number of total analgesic in this group was more than control group. Incidence of first group adverse events was less in study group but there was no significant difference between first group adcerse events in two groups. Conclusion: Use of celecoxib clinically had valuable efficacy in control of postoperative pain after third molar surgery and reduced intake of ibuprofen in patients. Although there was no significant difference between pain intensity in two groups. It appears that because of reducing intake of ibuprofen and fewer first group advers events use of celecoxibe 200mg per 12 hours and ibuprofen PRN is suggested in the patients with first group problems. However in individuals without first group problems, intake of ibuprofen alone is suggested. Key words: Celecoxib, Ibuprofen, Molar surgery, VAS index.