CLINICAL STUDY OF ASSOCIATED GALLSTONES IN COLON CANCERS

A total of 236 cases operated on for colon cancer in a recent 5 year period was compared for the location of tumor, s-Tchol and s-TG by grouping on whether gallstone was associated or not, and whether cholecystectomy had been done or not. Fecal bile acid deviation before and after cholecystectomy was also comparatively studied in 33 gallstone cases. Twenty-eight cases (11.9%) out of the 236 were accompanied by gallstones. When the cecum and ascending colon were regarded as right side and the discending colon, sigmoid colon and rectum as left side, the proportion occupied right side colon was 33.3% in the associated gallstone group, which was higher than 18.3% in non-associated group with a significant difference (p<0.05). There was same tendency in the location of tumor evaluated by whether cholecystectomy had been done or not. And we didn't recognize any significance in s-Tchol and s-TG evaluated by whether cholecystectomy had been done or not. No significant change in fecal bile acid deviation was also noted between before and after cholecystectomy. Therefore we think that colon cancers and gallstones may have the common risk factors, and besides, we disagree with some reports that cholecystectomy promotes the colon cancer.