HLA-B/HLA-C Region as a marker of psoriasis type I in Croatian patients

Psoriasis (PV) is a chronic skin disease strongly associated with several susceptibility genes. Recent genome - wide linkage anlyses have identified a locus susceptibility to PV (PSOR 1), which is pad of HLA region (HLA-B/HLA-C) maped on chromosome 6 p 21.3. The aim of the study was to indentify risk HLA alleles and haplotypes associated with type I PV according to the age on onset. Total 138 unrelated patients with type I PV (early onset < 40 years). Haplotype analyses revealed that early psoriasis onset (<20 years)is more significantly associated with B*13-Cw*0602 haplotype (p=0.006 for type Ia), than with B*57-Cv*0602 (p=0.0139 for type Ia).