Benefical Effect Of Aloe vera gel and Mango pulp ON Streptozotocin- Induced Diabetic Rats And Its Regulation On Oxidative Enymes of Heart And Kidney

Natural dietary supplements are essential for the treatment of Diabetes mellitus and its complications. So in our study we focused on combined effect of Aloe vera gel and Mango pulp on oxidative enzymes of heart and kidney of rat . In the present work eight groups of rats were taken Group – I,II and III were treated as control rats, Group – IV,V,VI,VII and VIII as experimental groups. As the oxidative enzymes play a key role in carbohydrate metabolism pathway and it is expected changes in citric acid cycle during diabetes. Hence it is essential to understand the function of some of the important marker enzymes and to find out their correlation with dietary supplements and diabetes. An attempt has been made in the present study to analyze the activity of dehydrogenase enzymes like MDH, SDH and LDH in both control and experimental rat kidney and heart tissues, as they exhibit important role in ATP production and in electron transport system also. The result reveals that MDH and SDH activities were decreased in Diabetes induced group and in contrast the LDH was increased. On treatment with Aloe vera gel and Mango pulps individually and in combination of both the alterations in the oxidative enzymes of heart and kidney were reestablished. Thus from these findings , it is possible to recommend natural dietary supplements such as mango pulp and Aloe vera gel for control of sugars in diabetic patients without any side effects.