Association Between Apolipoprotein E Gene Polymorphism and Cerebral Infarction in Chinese Han Population A Meta-Analysis

Objective： To systematically review the association between apolipoprotein E （APOE） gene polymorphism and cerebral infarction in Chinese Han population. Methods： The pertinent literature of the gene polymorphism and the case control studies of cerebral infarction in Chinese Han population were researched comprehensively by combined application of 5 effective retrieval approaches. The odds ratio （OR） of the genotype distribution in cerebral infarction group and control group were calculated. Results： A total of 1986 patients with cerebral infarction and controls were included in the meta-analysis. After the data were pooled, the OR values of ApoE e3/e3, APOE e3/e3, ApoE e2/e4, APOE e3/e4, and ApoE e4/e4 were 0.59 （95% CI, 0.44-0. 79）, 0. 52 （95% CI, 0. 40-0. 69）, 2.00 （95% CI, 1.22-3.28）, 2.77 （95% CI, 1.60-4. 81）, and 4.66 （95% CI, 1.61-13.48）, respectively. Conclusions： APOEe2/e4, ApoEe3/e4 and APOE e4/e4 genotypes are the risk factors of cerebral infarction. ApoE e2/e3 and APOE e3/e3 genotypes are the protective factors of cerebral infarction. Key words: apolipoprotein E;  gene polymorphism;  cerebral infarction;  a meta-analysis