Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels

Hellíada Vasconcelos Chaves,Danielle Rocha do Val,Kátia Alves Ribeiro,Jonas Cavalcante Lemos,Ricardo Basto Souza,Francisco Isaac Fernandes Gomes,Rodrigo Maranguape Silva da Cunha,Vicente de Paulo Teixeira Pinto,Gerardo Cristino-Filho,Marcellus H.L.P. Souza,Mirna Marques Bezerra,Gerly Anne de Castro Brito

Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels

2018

Hellíada Vasconcelos Chaves
Danielle Rocha do Val
Kátia Alves Ribeiro
Jonas Cavalcante Lemos
Ricardo Basto Souza
Francisco Isaac Fernandes Gomes
Rodrigo Maranguape Silva da Cunha
Vicente de Paulo Teixeira Pinto
Gerardo Cristino-Filho
Marcellus H.L.P. Souza
Mirna Marques Bezerra
Gerly Anne de Castro Brito

Objective and design To investigate the role of heme oxygenase-1 (HO-1), carbon monoxide (CO), and biliverdin (BVD) in the zymosan-induced TMJ arthritis in rats.

Keywords:

Biology
Biochemistry
Inflammation
Heme oxygenase
Arthritis
Biliverdin
Carbon monoxide
Heme
k channels

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