A convenient microwave-assisted desulfitative dimethylamination of the 2(1H)-pyrazinone scaffold using N,N-dimethylformamide

Abstract A convenient microwave-assisted methodology is developed for the generation of 5-chloro-3-(dimethylamino)pyrazin-2(1 H )-ones. The method entails a chemoselective desulfitative removal of a phenylthioether bond upon DMF/H 2 O treatment in the presence of sodium carbonate, yielding the desired compounds in 73–96%.