Four-component alpha-bromo-beta-phosphoalkoxylation of aromatic alpha,beta-unsaturated carbonyl compounds
2015
novel alpha-bromo-beta-phosphoalkoxylated carbonyl compounds were produced in moderate to excellent yields via highly selective four-component reaction involving nbs, a cyclic ether, an organic phosphate and an aromatic alpha,beta-unsaturated carbonyl compound. a number of experimental observations suggested that the reaction is likely initiated by an acid mediated nucleophilic conjugate addition followed by electrophilic trapping the enol intermediate and subsequent ring-opening of the cyclic ether.
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