Unravelling the anti-carbamylated protein antibody response in rheumatoid arthritis
2019
Although quite some data is available on anti-CarP
antibodies, several questions remain unanswered, including the
reproducibility of the clinical data on anti-CarP antibodies, such as their
presence before disease onset and association with joint damage. It is also
unknown whether these findings can be expanded to non-caucasian populations.
Furthermore, it is unclear how anti-CarP antibodies are induced, what
proteins they recognize, whether they are able to recognize multiple
carbamylated proteins and what the characteristics of these autoantibodies
are. Here, some of these questions will be answered. In this thesis, I will first discuss the clinical implications of the
presence of anti-CarP antibodies compared to RA-specific autoantibodies in
both RA patients other relevant conditions (chapters 2 till 7). This is followed
by more detailed investigations into the characteristics of anti-CarP
antibodies and their antigens (chapters 8 till 12).
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