New antifouling macrodiolides from the deep-sea-derived fungus Trichobotrys effuse DFFSCS021

A new symmetric 16-membered macrodiolide, trichobotryside A (1), and two new asymmetric 18-membered macrodiolides trichobotrysides B–C (2–3) were obtained from the deep-sea-derived fungus Trichobotrys effuse DFFSCS021. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of 1 and 2 were established by the methanolysis and modified Mosher method. And the methanolysis of both 1 and 2 produced the new compound of 4R,7S,9S-trihydroxyl-2-en-1-methyl decanoate (4). It was rare to obtain an 18-membered macrodiolide from nature. Compound 1 showed strong antifouling activity against Bugula neritina and Balanus amphitrite larvae settlement.