Expression and Clinical Significance of Survivin in Transitional Cell Bladder Carcinoma

Objective To investigate the expression of survivin and its clinical significance in human transitional cell bladder carcinoma. Methods Immunohisto-chemistry method was used to detect survivin expression in 75 cases of bladder transitional cell carcinoma The relationship between survivin expression and the clinicopathologic parameters and prognosis was retrospectively analyzed. Result Survivin expression was not detected in healthy bladder mucosa.Survivin expression was positive in 35 of 75(46.7%).The survivin expression positive rate in grade Ⅰ、Ⅱ and Ⅲ tumors was 26.9(7/20),48.5%(16/33)、75.0%(12/16) and in stage Tis～T 1 and T 2～T 4 tumors 34.2%(14/41) and 61.8% (21/34).The survivin expression positive rates were significantly higher in poorly differentiated and invasive bladder cancer.Expression of survivin was correlated well with histological grade、clinical stage and prognosis. Conclusions There was an important role of survivin expression in the development and for the progression of bladder cancer.Survivin expression could be used as a tumor marker for bladder cancer.