Clinical characteristics of MOG antibody disease: two case reports.

Serum myelin oligodendrocyte glycoprotein (MOG) antibody-mediated idiopathic inflammatory demyelinating disease (IIDDs), a type of central nervous system demyelinating disease with MOG antibodies positive in serum, referred to as MOG antibody disease. This is different from multiple sclerosis (MS) or optic neuromyelitis lineage disease (NMOSD) because of its relatively unique clinical features, imaging findings, and special biomarkers, and it is now considered to be an independent disease. Disease syndrome mainly includes single or bilateral optic neuritis (ON), long-segment transverse myelitis (LETM), transverse myelitis (TM), optic neuritis plus transverse myelitis (ON+TM)/AQP4 antibody-negative NMOSD, and acute disseminated encephalomyelitis (ADEM) [1]. In order to further understand the clinical characteristics of MOG antibody disease, we present two patients with MOG antibody disease admitted in our hospital.