Synthesis and SAR of α-sulfonylcarboxylic acids as potent matrix metalloproteinase inhibitors
2006
A series of novel carboxylic acid-based α-sulfone MMP inhibitors have been synthesized and the in vitro enzyme SAR is discussed. A potential binding mode in the active site of the MMP-9 homology model was highlighted. These compounds are potent MMP-9 inhibitors and are selective over MMP-1.
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