Lack of an association between cystatin C gene polymorphisms in Japanese patients with Alzheimer’s disease

Associations between polymorphisms of the cystatin C gene ( CST3 ) at 5′ flanking region and exon 1 in Caucasian patients with late onset AD and exon 1 in a US study of late onset AD have been reported. Clinically diagnosed Japanese patients with AD and Japanese normal control subjects were assessed for the presence of polymorphisms of CST3 . The authors could not confirm the previously reported association between CST3 polymorphisms and AD in Japan. Age had no effect on the CST3 genotype.