Morphofunctional and metabolic changes of intestinal wall in acute arterial ischemia

Successful gastrointestinal surgery is based on the precise knowledge of the morphological, functional and metabolic state of the bowel wall at a specific time point. Current trends include the development of real-time, minimally invasive, label-free and rapid techniques for tissue assessment in combination with algorithms of data processing. The aim of the study was to evaluate the performance of trans-serous multimodal optical coherence tomography (MM OCT) and FLIM macro-imaging in detecting changes in microstructure, blood circulation and metabolism of intestinal wall caused by acute arterial ischemia in experiment. The study was supported by the Russian Science Foundation, project No. 19-75-10096.