Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

Brigit E. Riley,Julie Lougheed,Kari Callaway,M. Velasquez,Eric Brecht,Lan Nguyen,Thomas A. Shaler,D. Walker,Y Yang,Karin Regnstrom,Linnea Diep,Z Zhang,San-San Chiou,Michael P. Bova,Dean R. Artis,Nanhua Yao,Jeanne Baker,Ted Yednock,Jennifer Johnston

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

2013

Brigit E. Riley
Julie Lougheed
Kari Callaway
M. Velasquez
Eric Brecht
Lan Nguyen
Thomas A. Shaler
D. Walker
Y Yang
Karin Regnstrom
Linnea Diep
Z Zhang
San-San Chiou
Michael P. Bova
Dean R. Artis
Nanhua Yao
Jeanne Baker
Ted Yednock
Jennifer Johnston

The Parkinson’s disease-associated protein Parkin regulates the fate of damaged mitochondria by ubiquitinating mitochondrial substrates. Riley et al. present the crystal structure of the Parkin-R0RBR domain, providing new insight into the catalytic mechanism of the enzyme.

Keywords:

Parkin
Ubiquitin ligase
Enzyme
Molecular biology
Genetics
DNA ligase
Ubiquitin-Protein Ligases
Mutation
Biology
Mitochondrion
Biochemistry
Protein structure

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