Analysis of 0-6 year-old children with isolated ventriculomegaly by Denver development screening test

Objective To investigate the intelligential development of 0-6 year-old children with different degrees and prognosis of isolated ventriculomegaly(IV) by Denver development screening test (DDST). Methods From 1st January 2007 to 1st January 2013, a total of 186 children with IV were selected as research group(n=186) in Affiliated Hospital of Jining Medical College. According to IV diagnostic criteria, they were further divided into mild IV subgroup (n=159), moderate IV subgroup (n=18) and severe IV subgroup (n=9).Meanwhile 200 normal children at the same hospital were chosen as the control group(n=200). The DDST results were compared between every subgroup and control group, respectively. And the relationship between abnormal and suspicious DDST results of children with IV and their age were observed. Results ①The DDST results showed that there were 8 abnormal cases (4.3%) and 16 suspicious cases (8.6%) in research group, 0 abnormal case and 4 suspicious cases (0.2%) in control group, and the difference had statistical significance between two groups(χ2=95.69, P<0.05).②The results of progressive type of mild IV subgroup, progressive and stable types of moderate IV subgroup and the three types of severe IV subgroup were respectively compared with the control group and all the differences were significant (χ2=15.99, 20.61, 35.16, 27.56, 14.41, 9.35; P<0.05). ③The incidence rates of abnormal and suspicious DDST results in research group were significantly correlated with their age(χ2=154.30, 159.09; P<0.05). ④ The intelligent developmental disorders of 24 children with abnormal and suspicious DDST results were as follow: speech disorder (54.2%), large motor development disorder (41.6%), fine movement disorder (33.3%) and personal and social disorder (16.7%). Conclusions The progressive type of mild IV, progressive and stable types of moderate dilatation, three types of severe dilatation, can lead to mental retardation. The proportion of mental retardation increases along with IV patients' age. Infants with high risk who are not found abnormal early need long-term follow-up, especially in the aspect of words and movement ability. Key words: Isolated ventriculomegaly; Prognosis; Growth and development; Screening