Therapeutic effectiveness of iodine-131 MIBG metastases of a nonsecreting paraganglioma

This case report describes the treatment of the bone metastases of a nonfunctioning sympathetic paraganglioma, with ( T I)MIBG. After primary tumor excision and unsuccessful external radiotherapy, the patient received three therapeutic doses of ( T I)MIBG, resulting in a reduction of the number and volume of metastases, and an improvement of the general condition. At 3 yr following ( T I)MIBG therapy, the patient remained in remission. ( T I)MIBG appears to be an efficient and safe agent for treating malignant sympathetic paraganglioma.