Cyclopalladation in pyrroles - some initiating studies

Cyclopalladation of arenes implies participation by an ortho co-ordinating substituent such as aldehyde, ketone, amide, hydrazino, aminoalkyl, azo, imine, and iminoether, thiazole, or thioalkyl in metallation of the arene. This process then, is a regioselective method for introduction of the metal, with replacement of hydrogen, generating intermediates which can be formulated generally as 1, and which are available for further manipulations involving use of the properties of the organometallic species.