90Y radioembolization for neuroendocrine cancers liver metastases provides sustained therapeutic effect with minimal toxicity.

343 Background: Radioembolization (RE) is the delivery of radioactive microspheres (90Y) via the hepatic artery, which permanently implant preferentially in metastatic lesions, sparing adjacent normal liver. Metastatic neuroendocrine tumors in the liver are a common clinical problem which can be treated with RE. It is an outpatient procedure performed with increasing frequency worldwide for a variety of solid tumor types. Methods: A single institution retrospective review of all neuroendocrine patients treated with radioactive resin microspheres to control hepatic metastases. Details reviewed included: specifics of treatment and delivery, RECIST response at 3 and 6 months, acute and delayed radiation toxicities by CTC3ae, and analyses of tumor and radiation factors related to response and liver control. Results: A total of 56 patients; 26 male, 30 female, received a total of 85 separate treatments with resin 90Y microspheres. Treatment volume was all hepatic tumors with each treatment, usually selective w...