Mycophenolate Mofetil Use For Lupus Nephritis During Pregnancy: Report Of A Case Of Fetal Malformations And Literature Update

Mycophenolate mofetil (MMF) is an immunosuppressive drug used to avoid rejection after solid organ transplantation and in the management of autoimmune diseases. There are few works describing its teratogenic effects when a woman becomes pregnant while taking MMF, but currently the recommendation is to avoid its use during pregnancy (classified category D by FDA). A case of major fetal malformations (cleft palate and micrognathia) is presented related to the use of MMF during pregnancy; the mother was affected by severe lupus nephritis and was taking MMF from before and throughout the pregnancy. All the cases of fetal malformations attributed to MMF are updated and review.