Synthesis of degradable cationic carbosilane dendrimers based on Si–O or ester bonds

Several cationic carbosilane dendrimers have been synthesized containing two different types of degradable bonds: Si–O and ester bonds. The first type of systems was prepared by reacting carbosilane dendrimers containing peripheral Si–Cl bonds with first generation dendrons presenting a –OH function at the focal point and amine peripheral functions. The second type of systems was prepared by esterification between a dendrimer containing acid groups and an alcoholamine. The stability in water of both types of cationic systems was evaluated.