Fabrication of ultrasound-mediated cerium oxide nanoparticles for the examinations of human osteomyelitis and antibacterial activity

In this work, two Gram-negative and three Gram-positive pathogenic pathogens were examined for the antibacterial activity of cerium oxide nanoparticles. CeO2 nanoparticles (CeO2 NPs) encapsulation with hydroxyapatite and chitosan were synthesised using the precipitation procedure and simultaneous reactant addition by techniques of a Wet Chemical Synthesis approach. Thermal analyses (TG–DTA), their degradation processes and their synthesis of CeO2 NPs were investigated, and the precursor powders were acquired. Fourier transform infrared (FTIR), X-ray diffraction, Raman spectroscopy, transmission electron microscopy (TEM), and dynamic light scattering (DLS) examined the thermally treated sample’s composition, structure, and morphology. CeO2 NPs antioxidant has also been determined. The analysis against five diseased pathogens, including Bacillus cereus, Staphylococcus aureus, Listeria monocytogenes, Salmonella typhimurium and Escherichia coli, has been performed on both fluid growth mediums. The growth inhibition of cerium oxide nanoparticles in all five pathogens studied exhibited noteworthy results. This study underlines the CeO2 NPs, which revealed considerable changes in antibacterial activity because of the changes in membrane structure and the composition of cell walls across the two test groups. As a result, generated CeO2 NPs can be prospective osteomyelitis therapy candidates.