AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family

Paul R. Gavine,Lorraine Mooney,Elaine Kilgour,Andrew Peter Thomas,Katherine Al-Kadhimi,Sarah Beck,Claire Rooney,Tanya Coleman,Dawn Baker,Martine J. Mellor,Brooks An,Teresa Klinowska

AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family

2012

Paul R. Gavine
Lorraine Mooney
Elaine Kilgour
Andrew Peter Thomas
Katherine Al-Kadhimi
Sarah Beck
Claire Rooney
Tanya Coleman
Dawn Baker
Martine J. Mellor
Brooks An
Teresa Klinowska

A potent and highly selective small-molecule inhibitor may offer a broad-based approach for treatment of many kinds of tumors that involve activation of the fibroblast growth factor receptor.

Keywords:

Fibroblast growth factor receptor 3
Tropomyosin receptor kinase C
Fibroblast growth factor receptor
Receptor tyrosine kinase
Cancer research
ROR1
Tyrosine kinase
Growth factor receptor inhibitor
Molecular biology
Platelet-derived growth factor receptor
Medicine

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