Differentiating Between β-Lactam Induced Serum Sickness-Like Reactions and Viral Exanthem in Children Using a Graded Oral Challenge

ABSTRACT Background Serum sickness-like reactions (SSLR) are defined by the presence of rash (primarily urticaria), and joint complaints (arthralgia/arthritis) that are believed to occur due to a non-IgE mediated response to medications. However, similar reactions can occur due to viral infections, and it can be difficult to distinguish between the two. This may lead to unnecessary avoidance of the culprit antibiotic. Objective We aimed to evaluate children presenting with suspected SSLRs through a graded oral challenge (GOC). Methods All children referred to the Montreal Children’s Hospital for potential antibiotic allergy (β-Lactam or other antibiotics) and a clinical presentation compatible with SSLR were recruited for the study between March 2013 and February 2020. A standardized survey with questions on treatment, symptoms, and associated factors was completed and a GOC (10% and subsequently 90% of the oral antibiotic dose) was conducted. Patients with a negative GOC were contacted annually to query on subsequent antibiotic use. Results Among 75 patients presenting with suspected SSLRs, the median age was 2.0 years and 46.7% were males. Most reactions were attributed to amoxicillin. Amongst the 75 patients, 2.7% reacted immediately (within one hour) to an GOC and 4.0% had a non-immediate reaction. Of the 43 patients successfully contacted, 20 reported subsequent culprit antibiotic use of which 25.0% had a subsequent mild reaction (macular/papular rash). Conclusion This is the first and largest pediatric study to assess SSLR using a GOC. Our findings suggest that using a GOC is safe and appropriate for differentiating between β-lactam induced SSLR and viral exanthem in this population.