Suppression of Antigen-Antibody Reaction in Xenotransplantation

TTENTION has been focused on the potential usageof animal organs, as the shortage of organ donors isincreasing. Before the start of clinical xenotransplantation,however, certain Immunologic, physiologic, and infectiousproblems must be solved. Advancements in genetic engi-neering have made it possible to overcome severe xenograftrejection. Hyperacute rejection has reportedly been sup-pressed when organs from the transgenic pigs expressinghuman complement regulatory proteins such as DAF,CD59, or MCP were transplanted into primates.