Clinical observation of Atorvastatin Calcium Tablets combined with Piperazine Ferulate Tablets in treatment of diabetic nephropathy

Objective To explore the clinical effect of Atorvastatin Calcium Tablets combined with Piperazine Ferulate Tablets in treatment of diabetic nephropathy. Methods Patients(80 cases) with diabetic nephropathy in Hanzhong Central Hospital from November 2012 to January 2015 were randomly divided into control and treatment groups, and each group had 40 cases. The patients in the control group were po administered with Piperazine Ferulate Tablets on the basis of basic treatment, 2 tablets/time, twice daily. The patients in the treatment group were po administered with Atorvastatin Calcium Tablets on the basis of the control group, 20 mg/d, once daily. The patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the changes of renal function indexes 24 h urine protein, creatinine, and urea, triacylglycerol(TG), low density lipoproteins(LDL), high density lipoprotein(HDL), and total cholesterol(TC) in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 70.0% and 90.0%, respectively, and there were differences between two groups(P < 0.05). After treatment, renal function indexes 24 h urine protein, creatinine, and urea in two groups were significantly improved, and the difference was statistically significant in the same group(P < 0.05). And those renal function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). After treatment, lipid levels TG, LDL, and TC in two groups were significantly decreased, and HDL were increased with significant difference(P < 0.05). And those lipid levels in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Atorvastatin Calcium Tablets combined with Piperazine Ferulate Tablets has clinical curative effect in treatment of diabetic nephropathy, and can improve the renal function indexes and lipid levels with high safety, which has a certain clinical application value.