Meta-analysis of Chinese medicines for prevention and treatment of radiation esophagitis.

Abstract Objective To systematically assess the clinical effectiveness of Chinese medicines for prevention and treatment of radiation esophagitis by meta-analysis. Methods The articles were mainly retrieved from the “CHKD (China Hospital Knowledge Database) periodical full text databank”, the “China periodical full text databank”, the “CHKD doctor's and Master's degree student full text databank”, and the “China doctor's degree student thesis databank”, and they were selected according to the literature selection standard. The effects of Chinese medicines and Western medicines on radiation esophagitis were compared by meta-analysis. Results Based on 13 articles, we found that the effectiveness of Chinese medicines for prevention and treatment of radiation esophagitis was superior to Western medicines, with no obvious side effects. Meta-analysis showed that the total odds ratio was 0.426 and the 95% confidence interval was 0.368, 0.493. Conclusion Chinese medicines are superior to Western medicines in preventing and treating radiation esophagitis. However, some methodological problems in the literature may have affected the authenticity of the results. Therefore, more rigorous, multi-central, randomized controlled trials with a large sample size should be designed to obtain a more reliable conclusion.