Oxidation to C14O2 and conversion to fatty acids of C14-glucose in livers of normal, fasted and x-irradiated rats

Oxidation of glucose-1-C14 and of glucose-6-C14 to C14O2 was greater in slices and homogenates of livers of rats given 1000 r total-body x-irradiation and fasted 24–48 hours than in their nonirradiated fasted controls. The ratio: C14O2 from glucose-6-C14/C14O2 from glucose-1-C14 was not altered in homogenates either by fasting or by x-irradiation. In liver slices, the ratio was increased by fasting, per se, but was not affected by x-irradiation. In rats weighing 350–400 gm, hepatic conversion of glucose-1-C14 and of glucose-6-C14 to fatty acids was greater in the irradiated fasted animals than in nonirradiated fasted controls although the ratio: C14-fatty acids from glucose-6-C14/C14-fatty acids from glucose-1-C14 was not affected by irradiation. In rats weighing 160–200 gm, no difference in lipogenesis from either glucose-1-C14 or glucose-6-C14 was apparent between irradiated and control rats.