Urothelial Cancer: Markers Natural History & Pathophysiology Podium 9

tionnaire (PHQ-4). We investigated the influence of family history, age at diagnosis ( 65 vs i› 65 years), and biochemical recurrence (Followup: PSA 0.2ng/ml) on psychosocial distress. RESULTS: The prevalence of cancer-specific distress was 16.4%. Regarding specific concerns, feeling physically imperfect (12.3%) and fear of disease progression (6.2%) were most prevalent. Depression was prevalent in 6.0%, and anxiety in 6.3%. Age at diagnosis was associated with each psychosocial distress measure (p .001), i.e. younger patients showed higher distress. Furthermore, biochemical recurrence was associated with higher cancer-specific distress (p.001) and with higher depression as well as anxiety scores (p.01). Family history was not directly associated with the distress measures, and did not interact with age at diagnosis or biochemical recurrence. CONCLUSIONS: Patients without biochemical recurrence of prostate cancer showed low rates of psychosocial distress. Those who received diagnosis at age before 65 years and those who had a biochemical recurrence in the meantime reported higher cancer-specific distress, depression and anxiety. Surprisingly, family history of prostate cancer showed neither a direct nor a moderating effect on psychosocial distress. Our data do not allow to decide whether this is due to succesful coping, no known prostate cancer genes, or some other variables.