Second-line therapy in follicular lymphoma in the United States: Report of NLCS observational study.

8049 Background: The National LymphoCare Study (NLCS) collects data on disease presentation, treatment patterns, and clinical outcomes for 2736 patients with with follicular lymphoma diagnosed 2004-2007 in the USA. Patterns of initial management (Rx1) in this cohort were reported previously (Friedberg, JCO 2009). The current report describes patterns of second-line therapy (Rx2). Methods: Data from pts enrolled in NLCS with a diagnosis of FL and active Rx1 were analyzed to establish patterns of Rx2. Therapy after initial period of observation is considered Rx1 for this analysis. Results: Of 2736 pts enrolled, 1841 remain in active follow-up after median 4.9 years and 991 had received Rx2 with median TTRx2 from Rx1 of 11.1 mos. 325 began Rx2 within six months of beginning Rx1, and 521 within a year. Thus far, 252 pts have begun Rx2 > 2 yrs following Rx1. 89% of Rx2 were for progressive disease, 10% toxicity, and 1% both. Seventy-one (7.3%) of the 991 received XRT monotherapy, 62 (6.3%) received therapy as ...