Platypnea-Orthodeoxia syndrome in a patient with atrial septal defect and concomitant aortic root enlargement.
2021
We present the case of hypertensive and dislipidemic adult patient with a small ostium secundum
atrial septal defect with trivial left-to-right shunt in whom an increasing enlargement of the
aortic root and ascending aorta reversed the interatrial shunt causing severe dyspnea and
oxygen desaturation, constantly elicited during upright position and relieved when he resumed
the recumbent position (Platypnea-Orthodeoxia syndrome). Catheter-based closure of the
interatrial communication was associated with an immediate increase in systemic saturation and
long lasting marked clinical improvement.
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