Primary squamous cell carcinoma of the neovagina

Abstract Primary carcinomas arising in the neovagina are rare and this is the ninth reported case. Two adenocarcinomas and seven squamous cell carcinomas, including our own case, have been described. The type of carcinoma is related to the transplanted tissue. Although the optimal therapy is unclear, we would recommend surgical treatment rather than radiation therapy. This is based on our own experience and on observations reported in the literature. Regular follow-up of patients with an artificial vagina is mandatory.