The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction

This work was supported by the Instituto de Salud Carlos III, Ministerio de Economia y Competitividad [grants PI11/00327, PI13/1025, PI14/00312 and CIBER CB06/04/0071], and postgraduate research grant FI12/00198 awarded to F.A.; the Conselleria d'Educacio, Formacio i Ocupacio, Generalitat Valenciana [grants PROMETEO/2010/060, PROMETEOII/2014/035, ACOMP/2013/236 and GVA/2014/118] and postgraduate research grant ACIF/2013/136 awarded to M.P.; the Universitat Jaume I [grant P1.1B-2014/15]; the Ministerio of Economia y Competitividad [Juan de la Cierva contract JCI-2012–15124 to A.B.-G.]; the Ministerio de Sanidad and Generalitat Valenciana [contract CES10/030 to V.M.V]; and the Ministerio de Educacion, Cultura y deporte [postgraduate research grant FPU13/00151 to A.M.-R.].