OP 7 Preeclampsia and the risk of later renal disease

Background Preeclampsia (PE), a pregnancy disorder often characterized by renal complications, has previously been associated with later end-stage renal disease. We conducted a nationwide register-based cohort study to explore associations between PE and later kidney disease. Methods Using Danish health registers, we identified all women with pregnancies lasting ⩾20 weeks in Denmark, 1978–2015. PE included preeclampsia, eclampsia or HELLP syndrome registered from 30 days before delivery to 7 days postpartum and was classified as early preterm, late preterm or term based on timing of delivery ( Results The study cohort consisted of 1,072,330 women followed for 19,994,470 person-years (average: 18.6 years/woman). During follow-up, 6060 women developed acute kidney disease and 3082 developed chronic kidney disease. Compared with women without PE delivering in the same gestational age interval, women with a history of PE had only modestly increased rates of acute kidney disease, but significantly higher rates of post-pregnancy chronic kidney disease: early preterm PE, HR 3.93, 95% confidence interval [CI] 2.90–5.33; late preterm PE, HR 2.81, 95% CI 2.13–3.71; term PE, HR 2.27, 95% CI 2.02–2.55. Associations for glomerular disease were especially striking (e.g. early preterm PE, HR 5.27, 95% CI 3.32–8.35). Conclusion Our study provides the first population-based evidence that PE, early PE in particular, is associated with several types of kidney disease later in life.