Diagnóstico y seguimiento de cáncer de piel no-melanoma utilizando 99mTc-MIBI. Estudios en un modelo animal

The aim of the work was to evaluate the usefulness of 99m Tc-MIBI as a tracer for the tumor diagnosis and progression of NMSC in a chemically induced model in mice. After administration of 99m Tc-MIBI animals were sacrificed at different times. Samples of tumor and healthy skin were dissected in order to perform histological analysis and to evaluate 99m Tc-MIBI uptake. Animals under 22 weeks of tumor evolution showed a statistically difference in 99m Tc-MIBI uptake between healthy skin and NMSC. Our results showed that the better protocol for the study of the tumor diagnosis and progression of NMSC in mice is the administration of 1 mCi of 99m Tc-MIBI and acquisition of images 30 minutes post injection. Results showed that, as tumor progresses, the uptake of 99m Tc-MIBI is significantly lower than healthy skin.