EP739 Significance of brain metastases in gynaecological cancer patients

Introduction/Background Brain metastasis is the most common brain tumors. Brain metastasis is rare in gynaecological cancer, whereas it occurred in 10–30% in other types of cancer. Our aim is to clarify the clinical significance of brain metastasis and assess prognostic factors in those patients. Methodology Clinical data of the gynaecological cancer patients who had a brain metastasis were collected from medical records in our center between 2007 and 2019. Results We found 18 patients with gynaecological cancer had brain metastases. Nine, five, three and one patients had ovarian, endometrial, cervical cancer and uterine sarcoma, respectively. One, two, nine and six patients were stage I, II, III and IV, respectively. The most common hisotypes were serous and endometriod carcinoma. The median age at diagnosis of brain metastasis was 56.5 years (range 39–83), the median size of the metastasis was 31 mm (range 10–70). Fourteen patients (77.8%) had solitary brain metastasis, and six patients (33.3%) had extracranial metastases. The most common part of brain metastasis was frontal part (38.9%) and secondary was cerebellum (27.8%). Three of 18 patients had carcinomatous meningitis. Headache (38.9%) was the most common symptoms, and only one patient appeared without symptom. Seven patients (38.9%) were treated with radiation therapy only and 10 patients (55.6%) were treated with combination therapy. The median time from initial treatment to brain metastasis was 17.5 months (range 0–67). The median overall survival after diagnosis of brain metastasis was 22.0 months (range 2–44). Conclusion Gynaecological cancer patients with headache had possibility of brain metastasis. Disclosure Nothing to disclose.